She began her career by participating in and winning several singing competitions, the first of which was in the long-running Philippine variety show Eat Bulaga! at age eleven. She rose to fame when she emerged as the Grand Champion of the reality talent search Search for a Star in 2004. She was previously managed by VIVA Artist Agency and Viva Records. She is currently managed by Cornerstone Talent Management Center.
Go won the Silver Prize award for her song, "From The Start", at the Shanghai Music Festival 2005 and Best Own song, "Isang Lahi", at the Astana International Song Festival 2005 in Astana, Kazakhstan. Since then, she has headlined concerts locally and internationally, recorded seven albums, which became certified gold and double platinum records.
Go has also performed in various hit musicals in the Philippines, London's West End and on Broadway. Her debut was in The Little Mermaid, playing the role of Ariel in 2011, for which she won a Best Actress award from Broadway World Philippine Awards; and another in 2013 for Tarzan, playing the role of Jane Porter. Go's theater career continues as she was cast in the 2014 West End revival of the hit musical Miss Saigon, for the role of Gigi Van Tranh. Following this, she was cast in the 30th anniversary staging of Les Miserables in the role of Fantine. She then made her Broadway debut reprising the role of Gigi in the Broadway revival of Miss Saigon in March 2017. Go is currently playing the role of Eliza Hamilton in the original West End production of Hamilton.
On April 27, 2016, it was announced that Go, along with Kyla, Yeng Constantino, KZ Tandingan, Angeline Quinto would be staging a concert at the Smart Araneta Coliseum, however, on September 1, 2016, Go was removed from the group because of many international commitments, including a major project abroad. No one replaced Go in the group, and the concert pushed through with the 4 remaining members.
In late 2019, Go returned to the Philippines, and performed for the 20th Anniversary of Francis Libiran titled Dare to Dream.
In 2020, she will hold a homecoming concert at the Marriott Grand Ballroom: Resorts World Manila.